Prostate cancer is the most common cancer in men worldwide and the second leading cause of cancer death in the United States. One of the prognostic features in prostate cancer is the Gleason grading of histopathology images. The Gleason grade is assigned based on tumor architecture on Hematoxylin and Eosin (H&E) stained whole slide images (WSI) by the pathologists. This process is time-consuming and has known interobserver variability. In the past few years, deep learning algorithms have been used to analyze histopathology images, delivering promising results for grading prostate cancer. However, most of the algorithms rely on the fully annotated datasets which are expensive to generate. In this work, we proposed a novel weakly-supervised algorithm to classify prostate cancer grades. The proposed algorithm consists of three steps: (1) extracting discriminative areas in a histopathology image by employing the Multiple Instance Learning (MIL) algorithm based on Transformers, (2) representing the image by constructing a graph using the discriminative patches, and (3) classifying the image into its Gleason grades by developing a Graph Convolutional Neural Network (GCN) based on the gated attention mechanism. We evaluated our algorithm using publicly available datasets, including TCGAPRAD, PANDA, and Gleason 2019 challenge datasets. We also cross validated the algorithm on an independent dataset. Results show that the proposed model achieved state-of-the-art performance in the Gleason grading task in terms of accuracy, F1 score, and cohen-kappa. The code is available at https://github.com/NabaviLab/Prostate-Cancer.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Recent advances in generative adversarial networks (GANs) have demonstrated the capabilities of generating stunning photo-realistic portrait images. While some prior works have applied such image GANs to unconditional 2D portrait video generation and static 3D portrait synthesis, there are few works successfully extending GANs for generating 3D-aware portrait videos. In this work, we propose PV3D, the first generative framework that can synthesize multi-view consistent portrait videos. Specifically, our method extends the recent static 3D-aware image GAN to the video domain by generalizing the 3D implicit neural representation to model the spatio-temporal space. To introduce motion dynamics to the generation process, we develop a motion generator by stacking multiple motion layers to generate motion features via modulated convolution. To alleviate motion ambiguities caused by camera/human motions, we propose a simple yet effective camera condition strategy for PV3D, enabling both temporal and multi-view consistent video generation. Moreover, PV3D introduces two discriminators for regularizing the spatial and temporal domains to ensure the plausibility of the generated portrait videos. These elaborated designs enable PV3D to generate 3D-aware motion-plausible portrait videos with high-quality appearance and geometry, significantly outperforming prior works. As a result, PV3D is able to support many downstream applications such as animating static portraits and view-consistent video motion editing. Code and models will be released at https://showlab.github.io/pv3d.

基于图像的3D检测是自主驾驶感知系统的必不可少的组成部分。但是，它仍然受到不满意的表现，这是有限的培训数据的主要原因之一。不幸的是，在3D空间中注释对象是极度时间/资源消耗的，这使得很难任意扩展训练集。在这项工作中，我们专注于半监督的方式，并探索更便宜的替代方案（即伪标记）的可行性，以利用未标记的数据。为此，我们进行了广泛的实验，以研究伪标签是否可以在不同环境下为基线模型提供有效的监督。实验结果不仅证明了基于图像的3D检测的伪标记机制的有效性（例如，在单眼设置下，我们在没有铃铛和哨声的Kitti-3D测试集上实现了20.23 AP，用于中等水平，从6.03 AP），但还显示了几个有趣且值得注意的发现（例如，经过伪标签训练的模型的性能要比基于相同培训数据的地面真相注释训练的表现更好）。我们希望这项工作可以在半监督环境下为基于图像的3D检测社区提供见解。代码，伪标签和预培训模型将公开可用。

深度学习（DL）模型为各种医学成像基准挑战提供了最先进的性能，包括脑肿瘤细分（BRATS）挑战。然而，局灶性病理多隔室分割（例如，肿瘤和病变子区）的任务特别具有挑战性，并且潜在的错误阻碍DL模型转化为临床工作流程。量化不确定形式的DL模型预测的可靠性，可以实现最不确定的地区的临床审查，从而建立信任并铺平临床翻译。最近，已经引入了许多不确定性估计方法，用于DL医学图像分割任务。开发指标评估和比较不确定性措施的表现将有助于最终用户制定更明智的决策。在本研究中，我们探索并评估在Brats 2019-2020任务期间开发的公制，以对不确定量化量化（Qu-Brats），并旨在评估和排列脑肿瘤多隔室分割的不确定性估计。该公制（1）奖励不确定性估计，对正确断言产生高置信度，以及在不正确的断言处分配低置信水平的估计数，（2）惩罚导致更高百分比的无关正确断言百分比的不确定性措施。我们进一步基准测试由14个独立参与的Qu-Brats 2020的分割不确定性，所有这些都参与了主要的Brats细分任务。总体而言，我们的研究结果证实了不确定性估计提供了分割算法的重要性和互补价值，因此突出了医学图像分析中不确定性量化的需求。我们的评估代码在HTTPS://github.com/ragmeh11/qu-brats公开提供。

基于深度神经网络（DNN）的智能信息（IOT）系统已被广泛部署在现实世界中。然而，发现DNNS易受对抗性示例的影响，这提高了人们对智能物联网系统的可靠性和安全性的担忧。测试和评估IOT系统的稳健性成为必要和必要。最近已经提出了各种攻击和策略，但效率问题仍未纠正。现有方法是计算地广泛或耗时，这在实践中不适用。在本文中，我们提出了一种称为攻击启发GaN（AI-GaN）的新框架，在有条件地产生对抗性实例。曾经接受过培训，可以有效地给予对抗扰动的输入图像和目标类。我们在白盒设置的不同数据集中应用AI-GaN，黑匣子设置和由最先进的防御保护的目标模型。通过广泛的实验，AI-GaN实现了高攻击成功率，优于现有方法，并显着降低了生成时间。此外，首次，AI-GaN成功地缩放到复杂的数据集。 Cifar-100和Imagenet，所有课程中的成功率约为90美元。

我们考虑使用系统的光学成像过程与卷积神经网络（CNN）来解决快照高光谱成像重建问题，其使用双相机系统以压缩方式捕获三维高光谱图像（HSIS）。近年来已经开发了使用CNN的各种方法来重建HSI，但大多数监督的深度学习方法旨在符合捕获的压缩图像和标准HSI之间的蛮力映射关系。因此，当观察数据偏离训练数据时，学习的映射将无效。特别是，我们通常在现实方案中没有地面真相。在本文中，我们提出了一个自我监督的双摄像机设备，具有未经训练的物理信息的CNNS框架。广泛的模拟和实验结果表明，我们没有培训的方法可以适应具有良好性能的广泛成像环境。此外，与基于培训的方法相比，我们的系统可以在现实方案中不断微调和自我改善。

基于深度学习的图像识别系统已广泛部署在当今世界的移动设备上。然而，在最近的研究中，深入学习模型被证明易受对抗的例子。一种逆势例的一个变种，称为对抗性补丁，由于其强烈的攻击能力而引起了研究人员的注意。虽然对抗性补丁实现了高攻击成功率，但由于补丁和原始图像之间的视觉不一致，它们很容易被检测到。此外，它通常需要对文献中的对抗斑块产生的大量数据，这是计算昂贵且耗时的。为了解决这些挑战，我们提出一种方法来产生具有一个单一图像的不起眼的对抗性斑块。在我们的方法中，我们首先通过利用多尺度发生器和鉴别器来决定基于受害者模型的感知敏感性的补丁位置，然后以粗糙的方式产生对抗性斑块。鼓励修补程序与具有对抗性训练的背景图像一致，同时保留强烈的攻击能力。我们的方法显示了白盒设置中的强烈攻击能力以及通过对具有不同架构和培训方法的各种型号的广泛实验，通过广泛的实验进行黑盒设置的优异转移性。与其他对抗贴片相比，我们的对抗斑块具有最大忽略的风险，并且可以避免人类观察，这是由显着性图和用户评估结果的插图支持的人类观察。最后，我们表明我们的对抗性补丁可以应用于物理世界。

Weakly-supervised object localization aims to indicate the category as well as the scope of an object in an image given only the image-level labels. Most of the existing works are based on Class Activation Mapping (CAM) and endeavor to enlarge the discriminative area inside the activation map to perceive the whole object, yet ignore the co-occurrence confounder of the object and context (e.g., fish and water), which makes the model inspection hard to distinguish object boundaries. Besides, the use of CAM also brings a dilemma problem that the classification and localization always suffer from a performance gap and can not reach their highest accuracy simultaneously. In this paper, we propose a casual knowledge distillation method, dubbed KD-CI-CAM, to address these two under-explored issues in one go. More specifically, we tackle the co-occurrence context confounder problem via causal intervention (CI), which explores the causalities among image features, contexts, and categories to eliminate the biased object-context entanglement in the class activation maps. Based on the de-biased object feature, we additionally propose a multi-teacher causal distillation framework to balance the absorption of classification knowledge and localization knowledge during model training. Extensive experiments on several benchmarks demonstrate the effectiveness of KD-CI-CAM in learning clear object boundaries from confounding contexts and addressing the dilemma problem between classification and localization performance.

Face Anti-spoofing (FAS) is essential to secure face recognition systems from various physical attacks. However, recent research generally focuses on short-distance applications (i.e., phone unlocking) while lacking consideration of long-distance scenes (i.e., surveillance security checks). In order to promote relevant research and fill this gap in the community, we collect a large-scale Surveillance High-Fidelity Mask (SuHiFiMask) dataset captured under 40 surveillance scenes, which has 101 subjects from different age groups with 232 3D attacks (high-fidelity masks), 200 2D attacks (posters, portraits, and screens), and 2 adversarial attacks. In this scene, low image resolution and noise interference are new challenges faced in surveillance FAS. Together with the SuHiFiMask dataset, we propose a Contrastive Quality-Invariance Learning (CQIL) network to alleviate the performance degradation caused by image quality from three aspects: (1) An Image Quality Variable module (IQV) is introduced to recover image information associated with discrimination by combining the super-resolution network. (2) Using generated sample pairs to simulate quality variance distributions to help contrastive learning strategies obtain robust feature representation under quality variation. (3) A Separate Quality Network (SQN) is designed to learn discriminative features independent of image quality. Finally, a large number of experiments verify the quality of the SuHiFiMask dataset and the superiority of the proposed CQIL.